Amanda C Swart Selected Research

11-ketotestosterone

1/2019	The 11β-hydroxysteroid dehydrogenase isoforms: pivotal catalytic activities yield potent C11-oxy C19 steroids with 11βHSD2 favouring 11-ketotestosterone, 11-ketoandrostenedione and 11-ketoprogesterone biosynthesis.
11/2013	11β-hydroxyandrostenedione, the product of androstenedione metabolism in the adrenal, is metabolized in LNCaP cells by 5α-reductase yielding 11β-hydroxy-5α-androstanedione.

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Amanda C Swart Research Topics

Disease

13	Prostatic Neoplasms (Prostate Cancer) 01/2021 - 09/2013
6	Polycystic Ovary Syndrome (Syndrome, Stein-Leventhal) 01/2021 - 09/2015
4	Congenital Adrenal Hyperplasia (Hyperplasia, Congenital Adrenal) 01/2021 - 09/2015
3	Disease Progression 01/2021 - 01/2018
3	Congenital adrenal hyperplasia due to 21 hydroxylase deficiency 09/2020 - 11/2017
2	Cardiovascular Diseases (Cardiovascular Disease) 03/2014 - 02/2012
1	Hyperplasia 01/2021
1	Prostatic Hyperplasia (Benign Prostatic Hyperplasia) 01/2020
1	Adrenocortical Carcinoma 01/2019
1	Endocrine System Diseases (Endocrine Diseases) 03/2018
1	Disorders of Sex Development (Intersexuality) 03/2018
1	Neoplasms (Cancer) 10/2015
1	Autoimmune Diseases (Autoimmune Disease) 10/2015
1	Inflammation (Inflammations) 10/2015
1	Metabolic Diseases (Metabolic Disease) 02/2012
1	Hypertension (High Blood Pressure) 02/2012
1	Type 2 Diabetes Mellitus (MODY) 02/2012
1	Metabolic Syndrome (Dysmetabolic Syndrome X) 02/2012
1	Carcinoma (Carcinomatosis) 02/2012
1	Insulin Resistance 02/2012

Drug/Important Bio-Agent (IBA)

14	SteroidsIBA 01/2021 - 02/2012
12	AndrogensIBA 01/2021 - 09/2013
5	compound 21IBA 01/2021 - 01/2018
3	11-ketodihydrotestosteroneIBA 01/2018 - 09/2013
2	Hormones (Hormone)IBA 01/2021 - 02/2012
2	11-ketotestosteroneIBA 01/2019 - 11/2013
2	EnzymesIBA 03/2018 - 01/2018
2	Testosterone (Sustanon)FDA Link 01/2018 - 09/2013
2	Androstenedione (4 Androstene 3,17 dione)IBA 01/2018 - 09/2013
2	LigandsIBA 10/2015 - 09/2015
1	GenisteinIBA 01/2019
1	IsoenzymesIBA 01/2019
1	daidzeinIBA 01/2019
1	Prostate-Specific Antigen (Semenogelase)IBA 01/2019
1	Complement System Proteins (Complement)IBA 01/2018
1	Steroid 21-Hydroxylase (21 Hydroxylase)IBA 11/2017
1	Cytochrome P-450 Enzyme System (Cytochrome P450)IBA 11/2017
1	Progesterone FDA LinkGeneric 11/2017
1	GlucocorticoidsIBA 10/2015
1	Glucocorticoid Receptors (Glucocorticoid Receptor)IBA 10/2015
1	Androgen Receptors (Androgen Receptor)IBA 09/2015
1	Cortisone FDA Link 03/2014
1	Hydrocortisone (Cortisol)FDA LinkGeneric 03/2014
1	Oxidoreductases (Dehydrogenase)IBA 11/2013
1	adrenosteroneIBA 11/2013
1	Dihydrotestosterone (Androstanolone)IBA 09/2013
1	Dehydroepiandrosterone (DHEA)IBA 09/2013
1	aspalathinIBA 02/2012

Therapy/Procedure

5	Castration 09/2020 - 09/2013
1	Therapeutics 10/2015